ABSTRACT
Nutritional factors, mainly low protein intakes have been implicated in the pathogenesis of endomyocardial fibrosis (EMF), the incidence of which is high in Kerala. As there is only marginal protein deficiency in the Kerala population, this may not be a causative factor. Studies have revealed low levels of magnesium (Mg) in the serum of these patients and high concentration of glycosaminoglycans. Accumulation of glycosaminoglycan-associated Mg deficiency is observed in the serum of EMF patients. The heart tissue from autopsy samples of EMF patients also showed accumulation of glycosaminoglycans.
Subject(s)
Adult , Diet , Endomyocardial Fibrosis/epidemiology , Female , Glycosaminoglycans/metabolism , Humans , India/epidemiology , Magnesium/blood , Magnesium Deficiency/blood , Male , Myocardium/metabolism , Retrospective StudiesABSTRACT
Elevated levels of serum glycosaminoglycans (GAG), associated with hypomagnesemia were observed in patients of proven CAD and thrombotic stroke in Kerala. Serum lipid profile was normal in the majority of these patients, indicating that elevated serum GAG may be an even more reliable indicator of atherosclerosis than elevated serum total cholesterol or LDL cholesterol. Autopsy samples of carotid artery and aorta which had atheroma showed significantly higher GAG when compared to samples which showed no atheroma. Serum Mg levels were significantly lower in CAD and thrombotic stroke patients as compared to controls. Mg deficiency may be one of the factors involved in the increased level of GAG.
Subject(s)
Adult , Aged , Carotid Artery Thrombosis/blood , Coronary Disease/blood , Female , Glycosaminoglycans/blood , Humans , Lipids/blood , Magnesium/blood , Male , Middle AgedABSTRACT
Orchidectomy caused a significant decrease in the concentration of ascorbic acid and ascorbic acid-2-sulphate in tissues while administration of testosterone to these animals reverses this effect. Concentration of ascorbic acid in liver in experimental groups correlates with the activity of L-qualano-lactone oxidase and dehydroascorbatase in this tissue.
Subject(s)
Animals , Ascorbic Acid/metabolism , Male , Orchiectomy , Rats , Rats, Sprague-Dawley , Testosterone/pharmacology , Time FactorsABSTRACT
The effect of testosterone on lipid peroxides and antiperoxidative enzymes in normal and orchidectomised animals has been studied. Orchidectomy results in increased lipid peroxidation in the heart, while administration of testosterone to the animals reverses this to a certain extent. On the other hand the administration of testosterone to normal rats results in increased lipid peroxidation in the liver and heart.